Anti-Aging Ultra Cream

Overview of Anti-Aging Ultra Cream

Dosage Strength

Ascorbic Acid / Azelaic Acid / Alpha Lipoic Acid / Aloe Vera / Estriol / Progesterone 10/5/1/0.5/0.1/2% 30 mL Pump

General Information

As we become older, our skin loses its capacity to repair obvious symptoms of aging. Facial features may become less defined as skin loses its youthful firmness and elasticity, even as wrinkles become more apparent.

The Anti-Aging Ultra Cream is a blend of scientifically proven, efficient chemicals that may help to reduce the affects of aging on skin for a more youthful appearance.

Anti-Aging Ultra Cream accomplishes this through the use of seven ingredients:

  • Ascorbic Acid
  • Azelaic Acid
  • Alpha Lipoic Acid
  • Aloe Vera
  • Estriol
  • Progesterone

This combination of substances may act not only to improve the surface appearance of facial skin, but also to stimulate collagen formation beneath the skin, reducing the appearance of fine lines and wrinkles and providing a smoother, more refreshed appearance to the face.

Azelaic Acid
Azelaic acid is a chemical not only commonly found in various grains, but is also naturally synthesized by the yeast that exists on healthy skin.1

Azelaic acid is a potent antioxidant with powerful anti-inflammatory and antibacterial properties that may show promising results including2

  • Brigthen Skin Tone
  • Visibly Improve Skin Texture
  • Reduce The Visibility of Blemishes

Commonly used to treat acne, research has demonstrated that azelaic acid may be used to effectively treat rosacea, flaky skin, and hyper-pigmentation.3

Azelaic acid also functions as a keratolytic, which means it may help return abnormal growths on the skin back to normal.2

Ascorbic Acid
Although vitamin C is an important ingredient for overall health, when taken orally, very little reaches the skin. 4

As vitamin C levels in the skin fall with age5, supplementing levels directly in the skin may aid in the fight against collagen breakdown and oxidative stress. Clinical experiments have demonstrated that when applied topically, vitamin C may increase collagen synthesis and reduce the effects of free radicals, resulting in firmer and more youthful skin.

Alpha Lipoic Acid
ALA is both water and fat-soluble, allowing it to be easily absorbed through the skin’s lipid (fat) layers. It also acts as a free-radical fighter in the cell’s plasma membrane, acting as a powerful antioxidant. 7

When applied topically, ALA may provide numerous benefits to the skin. ALA has been shown to significantly reduce the look of under-eye circles, loss of firmness, and puffiness. 8

The anti-inflammatory impact of ALA may also aid in the reduction of noticeable blotchiness and redness, potentially resulting in more even skin tone. ALA may also aid to reduce the appearance of pores and provide skin a better glow. 9

Because of its ability to regulate the synthesis of nitric oxide, which impacts blood flow to the skin, ALA may also be a useful treatment for reducing apparent fine lines and wrinkles. 10

Aloe Vera
The Liliaceae family includes the cactus plant Aloe vera. It is endemic to dry areas such as those found in portions of Africa and India, and has been utilized in traditional medicine for millennia.

Auxin and Gibberellins are two hormones found in aloe vera. These two hormones contain wound healing and anti-inflammatory effects, which may help with skin look. 11 Aloe vera’s Gibberellins may also encourage the formation of new cells. Aloe vera can be used to promote skin healing with minimum scarring. 11

Estriol
One of the many functions of estrogen in the body is to stimulate the creation of collagen12, the underlying support structure of the skin. Collagen also helps to increase skin thickness and suppleness. The skin is an essential endocrine tissue that responds to estrogen. Skin may wither if estrogen is not present to promote development.

Estriol is a “weak” estrogen that can be produced from plants. Estriol does not need to be balanced by progesterone and may have little effect on the body. Estriol is an ideal estrogen for topical usage because studies indicates that it is largely absorbed through the skin rather than the bloodstream. 13

Progesterone
Progesterone is a hormone that is naturally produced in the body by the ovaries. It may assist to preserve a more youthful appearance by slowing the aging process of the skin caused by menopause. 14

References

1.Del Rosso, James Q. “Azelaic Acid Topical Formulations: Differentiation of 15% Gel and 15% Foam.” The Journal of Clinical and Aesthetic Dermatology 10.3 (2017): 37–40. Print.
2.Fariba Iraji, Ali Sadeghinia, Zabiholah Shahmoradi, Amir Hossein Siadat, Abolfazl Jooya. Efficacy of topical azelaic acid gel in the treatment of mild-moderate acne vulgaris. Department of Dermatology, Al-Zahra Hospital.
3.Cutis [01 Jan 1996, 57(1 Suppl):36-45]. Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies.
4.Farris PK. Topical vitamin C: a useful agent for treating photoaging and other dermatologic conditions. Dermatol Surg. 2005 Jul;31(7 Pt 2):814-7.
5.Rhie G1, Shin MH, Seo JY, Choi WW, Cho KH, Kim KH, Park KC, Eun HC, Chung JH. Aging- and photoaging-dependent changes of enzymic and nonenzymic antioxidants in the epidermis and dermis of human skin in vivo. J Invest Dermatol. 2001 Nov;117(5):1212-7.
6.Liu J1. The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview. Neurochem Res. 2008 Jan;33(1):194-203. Epub 2007 Jun 29.
7.University of Maryland Medical Center. http://www.umm.edu/health/medical/altmed/supplement/alphalipoic-acid.
8.Beitner, Harry. (2003). Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% α-lipoic acid related to photoageing of facial skin. The British journal of dermatology. 149. 841-9. 10.1046/j.1365-2133.2003.05597.x.
9.Beitner, Harry. (2003). Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% α-lipoic acid related to photoageing of facial skin. The British journal of dermatology. 149. 841-9. 10.1046/j.1365-2133.2003.05597.x.
10.Oregon State University. Linus Pauling Institute. http://lpi.oregonstate.edu/mic/dietary-factors/lipoic-acid.
11.Surjushe, Amar, Resham Vasani, and D G Saple. “ALOE VERA: A SHORT REVIEW.” Indian Journal of Dermatology 53.4 (2008): 163–166. PMC. Web. 19 Sept. 2017.
12.Stevenson, Susan, and Julie Thornton. “Effect of Estrogens on Skin Aging and the Potential Role of SERMs.” Clinical Interventions in Aging 2.3 (2007): 283–297. Print.
13.Schmidt JB1, Binder M, Demschik G, Bieglmayer C, Reiner A. Treatment of skin aging with topical estrogens. Int J Dermatol. 1996 Sep;35(9):669-74.
14.John R. Lee, M.D. Slowing the Aging Process With Natural Progesterone. https://www.bellissimomedical.com/pdf/case-studies/women/progesterone-benefits/slowing-aging-with-progesterone.pdf
15.Beitner H. Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol. 2003;149(4):841-849.
16.National Center for Biotechnology Information (2020). PubChem Compound Summary for CID 5756, Estriol.
17.Lexi-drugs. Lexicomp. Wolters Kluwer Health, Inc Riverwoods, IL.
18.Ali ES, Mangold C, Peiris AN. Estriol: emerging clinical benefits. Menopause. 2017;24(9):1081-1085.
Progesterone
Contraindications/Precautions
Ascorbic Acid
Azelaic Acid
19.Finacea (azelaic acid) topical gel package insert. Whippany, NJ: Bayer Healthcare; 2016 Aug.
20.Finacea (azelaic acid) 15% topical foam package insert. Whippany, NJ: Bayer HealthCare Pharmaceuticals Inc.; 2015 Jul.
21.Delgado BJ, Lopez-Ojedo W. Estrogen. StatPearls; 2020.
22.Azelex (azelaic acid) package insert. Irvine, CA: Allergan, Inc.; 2004 May.
23.Azelex (azelaic acid) package insert. Irvine, CA: Allergan, Inc.; 2004 May.
24.Azelex (azelaic acid cream) 20% [package insert]. Irvine, CA: Allergan; 2013.

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