Overview of Cholecalciferol Capsules
Dosage Strength5,000 IU, 10,000 IU, 25,000 IU, 50,000 IU
Vitamin D is a fat-soluble vitamin that comes in two forms: cholecalciferol (vitamin D3) and ergocalciferol (vitamin D4) (vitamin D2). Vitamin D is added to a variety of meals, including milk and cereal. Other dietary sources include fish liver oils, fatty fish, and vitamin D-supplemented eggs from hens. The changes in chemical structure between the two forms of vitamin D have no effect on metabolism or clinical reactions once activated within the body. Although animal research have shown that vitamin D3 is less harmful than vitamin D2, human studies have proven inconsistent. 1 Vitamin D is necessary for optimal bone growth and mineralization and is essential for proper calcium and phosphate balance. Patient-specific dose can be estimated by testing serum 25-hydroxyvitamin D [25(OH)D] concentrations, which represent all vitamin D sources (e.g., sunlight and dietary or from supplements). Although cholecalciferol is approved for use in a variety of diseases, its principal application is vitamin D replenishment, as well as the prevention and treatment of vitamin D insufficiency and rickets.
NOTE: Nutraceuticals are promoted in the United States under the Dietary Supplement and Health Education Act of 1994. (DSHEA). As a result, nutraceuticals are not subject to the same regulations as medicines; scientific evidence supporting stated benefit(s) is not always accessible for nutraceuticals. Consumers should also be aware that strict quality control requirements are not necessary for nutraceuticals, and significant fluctuation in both potency and purity can occur.
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6.Standing Committee on the Scientific Evaluation of Dietary Reference Intakes – Panel on Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine (IOM). Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. The National Academy of Sciences Press, Washington DC; 1997
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9.Hectorol® (doxercalciferol) package insert. Middleton, WI: Bone Care International, Inc.; 2005 Jun.
10.Drisdol® (ergocalciferol) package insert. New York, NY: Sanofi-Synthelabo, Inc.; 2003 Dec.
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14.Lanoxin® (digoxin) package insert. Research Triangle Park, NC: Glaxo Smith Kline; 2001 Aug.
15.Amin S, LaValley MP, Simms RW, et al. The role of vitamin D in corticosteroid-induced osteoporosis: an analytical approach. Arthritis Rheum 1999;42:1740—51.
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17.Questran® and Questran® Light (cholestyramine) package insert. Spring Valley, NY: Par Pharmaceutical Inc; 2002 July.
18.Xenical® (orlistat) package insert. Nutley, NJ: Roche Laboratories Inc.; 2005 Jan.
19.Hypponen E, Fararouei M, Sovio U, et al. High-dose vitamin D supplements are not associated with linear growth in a large Finnish cohort. J Nutr 2011;141:843-848.
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