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Estradiol Cream

Overview of Estradiol Cream

Dosage Strength

  • 0.2 mg/mL 30 mL Topi-Click Dispenser
  • 0.5 mg/mL 30 mL Topi-Click Dispenser
  • 0.625 mg/mL 30 mL Topi-Click Dispenser
  • 1 mg/mL 30 mL Topi-Click Dispenser
  • 2 mg/mL 30 mL Topi-Click Dispenser
  • 2.5 mg/mL 30 mL Topi-Click Dispenser
  • 3 mg/mL 30 mL Topi-Click Dispenser
  • 4 mg/mL 30 mL Topi-Click Dispenser
  • 5 mg/mL 30 mL Topi-Click Dispenser
  • 6 mg/mL 30 mL Topi-Click Dispenser
  • 7 mg/mL 30 mL Topi-Click Dispenser
  • 8 mg/mL 30 mL Topi-Click Dispenser
  • 9 mg/mL 30 mL Topi-Click Dispenser
  • 10 mg/mL 30 mL Topi-Click Dispenser
  • 20 mg/mL 30 mL Topi-Click Dispenser

General Information

The main intracellular human estrogen, estradiol, has a much higher level of cellular activity than its metabolites, estrone and estriol. You can make synthetic estradiol or get it from natural sources. There is no proof that “natural” estrogens are any safer or more effective than “synthetic” estrogens. 1 Estradiol must be administered in a micronized oral dose form to assure therapeutic action because first-pass metabolism is nearly complete. Estradiol can be administered parenterally intramuscularly because esterification of estradiol to estradiol cypionate or valerate lengthens its parenteral duration of action. In addition to treating female hypogonadism and other disorders of female gonadotropin malfunction, estradiol is principally used to prevent osteoporosis, ease vasomotor and genitourinary symptoms associated with menopause (natural or surgical), and prevent postmenopausal osteoporosis. Since 1938, a variety of estrogen-related products have been sold in the United States. There are numerous dosage forms for estradiol, including oral tablets, transdermal systems, topical emulsions, gels, and sprays, vaginal creams, rings, and parenteral depot injections. Because most of these dose forms have decreased systemic absorption/exposure, vaginal treatments are favored in postmenopausal women with just genitourinary complaints. 1 Since the 1990s, many estradiol medications have received FDA approval, following the FDA’s directive to offer effective low-dose estrogen therapy in different drug delivery systems.

References

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