Glutathione Injection

Overview of Glutathione Injection

Dosage Strength

200 mg/mL Preserved 30 mL Vial
200 mg/mL Preservative Free 30 mL Vial

General Information

Three amino acids are combined to generate the peptide known as glutathione (GSH), which is a potent antioxidant and plays a number of vital roles in the body. The level of glutathione in cells may be able to be used to forecast how long an organism will live, according to researchers who claim that this peptide is crucial for maintaining optimal health. 12

The enzymes glutathione S-transferases (GST) and glutathione peroxidases are catalyzed by glutathione (GPx). by getting rid of harmful electrophilic molecules and reactive peroxides, detoxification is aided. A detoxification system that is essential to plants, animals, and fungus depends on glutathione. 3

In addition to its involvement in detoxification, it is crucial for a number of crucial cellular processes. Its presence in the glyoxalase system is essential to the reduction of DNA and RNA nucleotides. Additionally, glutathione is a component in the exchange reactions that control thiol to disulfide ratios as well as the regulation of protein and gene expression. 4

Glutathione can reside intracellularly in two different chemical states: reduced glutathione and oxidized glutathione disulfide. It has been demonstrated that the ratio of reduced glutathione to glutathione disulfide, which is closely regulated, is essential for cell survival.

Glutathione deficiency increases the danger of oxidative damage to the cell. Numerous maladies, such as cancer, neurological diseases, cystic fibrosis (CF), HIV, and aging, exhibit an unbalanced glutathione level.

Although sustaining a healthy immune system depends on glutathione, the body can make its own from amino acids, therefore it is not considered an essential vitamin.

  • L-cysteine
  • L-glutamic acid
  • Glycine

Every cell in the body contains glutathione, which is one of the reasons it is so crucial for good health. By scavenging free radicals, which can damage cells through oxidation and are neutralized by antioxidants like glutathione, free radicals can be prevented from harming the body. Glutathione is well positioned to accomplish this because it is a natural component of all cell types. It’s regarded as one of the body’s most crucial antioxidants. 5

References

1.Richie JP Jr, Leutzinger Y, Parthasarathy S, Malloy V, Orentreich N, Zimmerman JA. Methionine restriction increases blood glutathione and longevity in F344 rats. FASEB J. 1994 Dec;8(15):1302-7.
2.Cascella R, Evangelisti E, Zampagni M, Becatti M, D’Adamio G, Goti A, Liguri G, Fiorillo C, Cecchi C. S-linolenoyl glutathione intake extends life-span and stress resistance via Sir-2.1 upregulation in Caenorhabditis elegans. Free Radic Biol Med. 2014 Aug;73:127-35. doi: 10.1016/j.freeradbiomed.2014.05.004. Epub 2014 May 15.
3.Anderson, M.E., Glutathione Injections: an overview of biosynthesis and modulation. Chem Biol Interact, 1998. 111-112: p. 1-14.
4.P., M. and C. G.P., Glutathione reductase: regulation and role in oxidative stress, in Oxidative stress and the molecular biology of antioxidant defenses. 1997, Cold Spring Harbor Laboratory Press
5.Lu, Shelly C. “REGULATION OF Glutathione SYNTHESIS.” Molecular aspects of medicine 30.1-2 (2009): 42–59. PMC. Web. 2 Oct. 2017.
6.Downey, J.S., et al., The LEC rat possesses reduced hepatic selenium, contributing to the severity of spontaneous hepatitis and sensitivity to carcinogenesis. Biochem Biophys Res Commun, 1998. 244(2): p. 463-7.
7.Banki, K., et al., Molecular ordering in HIV-induced apoptosis. Oxidative stress, activation of caspases, and cell survival are regulated by transaldolase. J Biol Chem, 1998. 273(19): p. 11944-53.
8.Shisler, J.L., et al., Ultraviolet-induced cell death blocked by a selenoprotein from a human dermatotropic poxvirus. Science, 1998. 279(5347): p. 102-5.
9.Okamoto, K., et al., Formation of 8-hydroxy-2′-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in human renal-cell carcinoma. Int J Cancer, 1994. 58(6): p. 825-9.
10.Chinery, R., et al., Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells. Cancer Res, 1998. 58(11): p. 2323-7.
11.Lee, Y.J., et al., Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells. J Biol Chem, 1998. 273(9): p. 5294-9.
12.P., M. and C. G.P.,
Glutathione reductase: regulation and role in oxidative stress, in Oxidative stress and the molecular biology of antioxidant defenses. 1997, Cold Spring Harbor Laboratory Press
13.Hauser, R.A., et al., Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson’s disease. Mov Disord, 2009. 24(7): p. 979-83.
14.Dröge W, Breitkreutz R. Glutathione and immune function. Proc Nutr Soc. 2000 Nov;59(4):595-600.
15.Chang WK, Yang KD, Chuang H, Jan JT, Shaio MF. Glutamine protects activated human T cells from apoptosis by up-regulating glutathione and Bcl-2 levels. Clin Immunol. 2002 Aug;104(2):151-60.
16.Oxidative Medicine and Cellular Longevity.Volume 2013 (2013), Article ID 972913, 10 pages http://dx.doi.org/10.1155/2013/972913.
17.pubchem.ncbi.nlm.nih.gov/compound/124886?from=summary#section=Related-Compounds
18.Balendiran GK1, Dabur R, Fraser D. The role of glutathione in cancer. Cell Biochem Funct. 2004 Nov-Dec;22(6):343-52.
19.Ballatori, Nazzareno et al. “Glutathione Dysregulation and the Etiology and Progression of Human Diseases.” Biological chemistry 390.3 (2009): 191–214. PMC. Web. 2 Oct. 2017.
20.Vogt, Barbara L., and John P. Richie. “Glutathione Depletion and Recovery After Acute Ethanol Administration in the Aging Mouse.” Biochemical pharmacology 73.10 (2007): 1613–1621. PMC. Web. 2 Oct. 2017.
21.Dimova S, Hoet PH, Dinsdale D, Nemery B. Acetaminophen decreases intracellular glutathione levels and modulates cytokine production in human alveolar macrophages and type II pneumocytes in vitro. Int J Biochem Cell Biol. 2005 Aug;37(8):1727-37. Epub 2005 Apr 26.
22.Abhilash, M., Varghese, M.V., Paul, M.V.S. et al. Comp Clin Pathol (2015) 24: 927. https://doi.org/10.1007/s00580-014-2013-8
23.Romero DL, Mounho BJ, Lauer FT, Born JL, Burchiel SW. Depletion of glutathione by benzo(a)pyrene metabolites, ionomycin, thapsigargin, and phorbol myristate in human peripheral blood mononuclear cells. Toxicol Appl Pharmacol. 1997 May;144(1):62-9.
24.National Research Council (US). Multiple Chemical Sensitivities: A Workshop. Washington (DC): National Academies Press (US); 1992. Considerations for the Diagnosis of Chemical Sensitivity.
25.Lenzi A1, Lombardo F, Gandini L, Culasso F, Dondero F. Glutathione therapy for male infertility. Arch Androl. 1992 Jul-Aug;29(1):65-8.
26.Coppola L, Grassia A, Giunta R, Verrazzo G, Cava B, Tirelli A, D’Onofrio F. Glutathione (Glutathione) improved haemostatic and haemorheological parameters in atherosclerotic subjects. Drugs Exp Clin Res. 1992;18(11-12):493-8.
27.Weschawalit, Sinee et al. “Glutathione and Its Antiaging and Antimelanogenic Effects.” Clinical, Cosmetic and Investigational Dermatology 10 (2017): 147–153. PMC. Web. 2 Oct. 2017.

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