Norditropin Injection

Overview of Norditropin Injection

Dosage Strength

  • 5 mg Flexpro Pen
  • 10 mg Flexpro Pen
  • 15 mg Flexpro Pen

General Information

Somatropin, rh-GH is a pure recombinant growth hormone produced in either Escherichia coli or mammalian cells. The pituitary gland produces endogenous human growth hormone (hGH). Growth hormone was isolated for the first time in 1956, and its structure was discovered in 1972. Prior until 1985, growth hormone (GH) was generated from human cadavers; however, the usage of human derived GH was discontinued due to Creutzfeldt-Jakob virus contamination of the product. Somatropin is approved for the treatment of growth hormone deficiency (GHD), growth failure, or short stature, as well as cachexia and AIDS wasting; it is also approved for the treatment of people with short bowel syndrome. Somatropin has been examined for the treatment of HIV-associated adipose redistribution syndrome (HARS); preliminary data suggest that it may reduce visceral adipose tissue. There are several somatropin medications available, each with a different indication and dosing regimen. Product selection should be done with caution because some products may not be interchangeable. The FDA initially approved somatropin in 1987.

References

1.Omnitrope (somatropin) package insert. Princeton, NJ: Sandoz, Inc.; 2016 Dec.
2.Genotropin (somatropin) package insert. New York, NY: Pharmacia & Upjohn Company; 2016 Dec.
3.Food and Drug Administration (US FDA) Drug Safety Communication. Safety review update of Recombinant Human Growth Hormone (somatropin) and possible increased risk of death. Retrieved August 4, 2011. Available on the WorldWide Web at: http://www.f
4.Albertsson-Wikland K, Martensson A, Savendalh L, et al. Mortality is not increased in recombinant human growth hormone-treated patients when adjusting for birth characteristics. J Clin Endocrinol Metab. 2016; 101: 2149-2159.
5.Humatrope (somatropin) package insert. Indianapolis, IN: Eli Lilly and Company; 2016 Dec.
6.Serostim (somatropin) package insert. Rockland, MA: EMD Serono, Inc.; 2017 May.
7.Nutropin (somatropin) package insert. San Francisco, CA: Genentech; 2016 Dec.
8.Accretropin (somatropin) package insert. Winnipeg, Canada: Cangene Corporation; 2016 Dec.
9.Nutropin AQ (somatropin) package insert. San Francisco, CA: Genentech; 2016 Dec.
10.Saizen (somatropin) package insert. Rockland, MA: EMD Serono Inc; 2017 May.
11.Norditropin (somatropin) package insert. Plainsboro, NJ: Novo Nordisk; 2016 Dec.
12.Zomacton (somatropin) package insert. Parsippany, NJ: Ferring Pharmaceuticals, Inc; 2016 Dec.
13.Zorbtive (somatropin) injection package insert. Rockland, MA: EMD Serono, Inc.; 2017 May.
14.Cook DM, Yuen KC, Biller BM, et al; American Association of Clinical Endocrinologists (AACE). American Association of Clinical Endocrinologists medical guidelines for clinical practice for growth hormone use in growth hormone-deficient adults and
15.The American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2015;63:2227-46.
16.Zomig (zolmitriptan) nasal spray package insert. Hayward, CA: Impax Specialty Pharma; 2015 Jun.

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