Omnitrope Injection

Overview of Omnitrope Injection

Dosage Strength

5.8 mg Lyophilized Vial

General Information

Somatropin (rh-GH) is a pure recombinant growth hormone produced in either Escherichia coli or mammalian cells. Endogenous human growth hormone (hGH) is produced in the pituitary gland. Growth hormone was initially isolated in 1956, and its structure was discovered in 1972. Prior until 1985, growth hormone (GH) was generated from human cadavers; however, the usage of human derived GH was discontinued due to contamination with the Creutzfeldt-Jakob virus. Somatropin is approved for the treatment of growth hormone deficiency (GHD), growth failure, or short stature, as well as cachexia and AIDS wasting; it is also recommended for individuals with short bowel syndrome. Somatropin has been explored in the treatment of HIV-associated adipose redistribution syndrome (HARS); limited short-term data suggest that it may reduce visceral adipose tissue. There are several somatropin medications on the market, each with a different indication and dose regimen. Product selection should be done with caution because products may not be interchangeable. Somatropin was first licensed by the FDA in 1987.

References

1.Omnitrope (somatropin) package insert. Princeton, NJ: Sandoz, Inc.; 2016 Dec.
2.Genotropin (somatropin) package insert. New York, NY: Pharmacia & Upjohn Company; 2016 Dec.
3.Food and Drug Administration (US FDA) Drug Safety Communication. Safety review update of Recombinant Human Growth Hormone (somatropin) and possible increased risk of death. Retrieved August 4, 2011. Available on the WorldWide Web at: http://www.f
4.Albertsson-Wikland K, Martensson A, Savendalh L, et al. Mortality is not increased in recombinant human growth hormone-treated patients when adjusting for birth characteristics. J Clin Endocrinol Metab. 2016; 101: 2149-2159.
5.Humatrope (somatropin) package insert. Indianapolis, IN: Eli Lilly and Company; 2016 Dec.
6.Serostim (somatropin) package insert. Rockland, MA: EMD Serono, Inc.; 2017 May.
7.Nutropin (somatropin) package insert. San Francisco, CA: Genentech; 2016 Dec.
8.Accretropin (somatropin) package insert. Winnipeg, Canada: Cangene Corporation; 2016 Dec.
9.Nutropin AQ (somatropin) package insert. San Francisco, CA: Genentech; 2016 Dec.
10.Saizen (somatropin) package insert. Rockland, MA: EMD Serono Inc; 2017 May.
11.Norditropin (somatropin) package insert. Plainsboro, NJ: Novo Nordisk; 2016 Dec.
12.Zomacton (somatropin) package insert. Parsippany, NJ: Ferring Pharmaceuticals, Inc; 2016 Dec.
13.Zorbtive (somatropin) injection package insert. Rockland, MA: EMD Serono, Inc.; 2017 May.
14.Cook DM, Yuen KC, Biller BM, et al; American Association of Clinical Endocrinologists (AACE). American Association of Clinical Endocrinologists medical guidelines for clinical practice for growth hormone use in growth hormone-deficient adults and
15.The American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2015;63:2227-46.

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