Spironolactone Tablets

Overview of Spironolactone Tablets

Dosage Strength

25 mg, 50 mg, 100 mg

General Information

Spironolactone is a diuretic that reduces potassium levels. When combined with standard medication, spironolactone has been demonstrated to increase overall survival, NYHA functional class, and hospitalizations in patients with severe heart failure (NYHA Class IV) (e.g., ACE inhibitor, loop diuretic, digoxin). 1 It is widely used to treat ascites caused by cirrhosis and has also been used to aid in the diagnosis of primary hyperaldosteronism. It is also employed in the treatment of hypokalemia. It is a relatively weak drug for treating hypertension or generalized edema when compared to thiazide or loop diuretics, yet its effects can be additive when used with thiazide diuretics. Spironolactone has been used to treat acne vulgaris, polycystic ovary syndrome, and female hirsutism, albeit these are not FDA-approved uses. The FDA authorized spironolactone in 1960.

References

1.Pitt B, Zannad F, Remme WJ. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 1999;341:709-717.
2.Aldactone (spironolactone) package insert. New York, NY: G.D. Searle LLC Division of Pfizer Inc.; 2020 Jun.
3.van der Vorst MMJ, Kist JE, van der Heijden AJ, et al. Diuretics in pediatrics: current knowledge and future prospects. Paediatr Drugs 2006: 8(4); 245-64.
4.Karim A. Spironolactone: disposition, metabolism, pharmacodynamics, and bioavailability. Drug Metab Rev 1978;8:151-88.
5.Carospir (spironolactone) oral suspension package insert. Farmville, NC: CMP Pharma, Inc.;2021 Jun.
6.Bornstein SR, Allolio B, Arlt W, et al. Diagnosis and treatment of primary adrenal insufficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2016;101:364-389.
7.Esposito D, Pasquali D, Johannsson G. Primary adrenal insufficiency: managing mineralocorticoid replacement therapy. J Clin Endocrinol Metab. 2018;103:376-387.
8.Inder WJ, Meyer C, Hunt PJ. Management of hypertension and heart failure in patients with Addison’s disease. Clin Endocrinol. 2015;82:789-792.
9.Hunt SA, Abraham WT, Chin MH, et al. 2009 Focused Update Incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults. Circulation 2009;119:e391-e479.
10.Carospir (spironolactone) oral suspension package insert. Farmville, NC: CMP Pharma, Inc.;2021 Jun.
11.American Academy of Pediatrics (AAP) Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics 2001;108(3):776-789.

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