Testosterone Enanthate Injection

Overview of Testosterone Enanthate Injection

Dosage Strength

Commercial: 200 mg/mL 5 mL Vial (Sesame Oil)
Compounded: 200 mg/mL 5 mL Vial (Grapeseed Oil)

General Information

The development of both main and secondary sexual traits that take place during puberty is triggered by the sex hormone known as testosterone, which is largely prevalent in males. It plays various significant roles in the physiological system of females and is also present in females, but in a lesser degree.

During the first few weeks of intrauterine life, the effects of testosterone often start to become noticeable. The Y chromosome causes the development of the primordial testes around the seventh week of gestation inside the uterus. The production of testosterone and Mullerian Inhibiting Factor, which are necessary for the differentiation of the baby into a male rather than a female, starts once the primordial testes are fully grown. In the final months of fetal development, the release of testosterone in the uterus causes the formation of the key physical features of males, including the epididymis, vas deferens, seminal vesicles, penis, prostate gland, and the descent of the testicles into the scrotum. 12

Males see a large increase in the amount of testosterone their bodies generate and release during puberty. The hypothalamic-pituitary-gonad axis is in charge of this rise in testosterone production. Gonadotropin-releasing hormone (GnRH), which is released by the hypothalamus in the brain, then passes through the hypothalamic-hypophyseal portal system to reach the anterior pituitary gland. GnRH triggers the release of luteinizing hormone (LH) and follicle stimulating hormone in the anterior pituitary gland (FSH). The Leydig cells in the testes respond to the released LH by producing more testosterone. When testosterone is released, it encourages the growth of secondary sexual traits in men, including bigger genitalia, a higher libido, the production of sperm, a deeper voice, and the development of male hair patterns on the body.

Male secondary sexual traits are developed by testosterone, but it also performs other crucial bodily tasks. Some of these tasks consist of:

Skeletal muscle: The muscle fibers in the skeletal muscular system are hypertrophic and hyperplastic in response to testosterone. Due to the hypertrophic effects of testosterone during puberty, there is a noticeably greater rise in muscle growth. The administration of testosterone has been demonstrated to help reverse muscle loss in men who are suffering it as a result of aging. 3

Bone: Testosterone significantly affects the formation and upkeep of bone growth. It is changed into estradiol by the enzyme aromatase, and estradiol reduces the loss of bone by preventing osteoclasts from resorbing it. Additionally, the enzyme 5-alpha reductase changes testosterone into dihydrotestosterone (DHT), which promotes bone osteoblasts and the formation of new bone.

Blood: Males’ red blood cell synthesis is stimulated by testosterone. This is one of the main explanations for why men often have higher amounts of red blood cells than women. Research is being done to better understand how testosterone increases the creation of red blood cells. 5

Brain: According to certain research, testosterone levels in the body have an effect on men’s capacity for higher-order cognitive skills including reasoning. These studies suggest that memory impairment, verbal and visual performance impairment, and some degree of hypogonadism, or low testosterone, may affect the majority of men. 6

Mood: Although it is also unclear how testosterone affects mood and behavior in men, it has been demonstrated that it does. Men with hypogonadism are more likely to experience depressed symptoms. Men with hypogonadism reported feeling happier after taking testosterone pills, according to research. 7

Males with low testosterone and other hypogonadism symptoms are typically treated with testosterone enanthate, an injectable testosterone supplement. It is a slow-release oil-based ester that can be injected intramuscularly or subcutaneously, depending on the patient or the healthcare provider’s desire. Since its first clinical application in 1937 to treat low testosterone, its use by males has seen a substantial rise in popularity. 8

References

1.Bain, J., “The many faces of testosterone”, Clinical Interventions in Aging, vol. 2 issue 4, pp. 567-576. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686330/
2.Nassar, G.N., Leslie, S.W., “Physiology, Testosterone”, StatPearls. Available: https://www.ncbi.nlm.nih.gov/books/NBK526128/
3.Atkinson, R.A., Srinivas-Shankar U., Roberts, S.A., Connolly, M.J., Adams, J.E., Oldham, J.A., Wu, F.C., Seynnes, O.R., Stewart, C.E., Maganaris, C.N., Narici, M.V., “Effects of Testosterone on Skeletal Muscle Architecture in Intermediate-Frail and Frail Elderly Men”, The Journals of Gerontology: Series A, Vol. 65A, issue 11, pp.1215–1219. November 2010. Available: https://academic.oup.com/biomedgerontology/article/65A/11/1215/596059
4.Mohamad, N. V., Soelaiman, I. N., , Chin, K. Y., “A concise review of testosterone and bone health”, Clinical interventions in aging, vol. 11, pp. 1317–1324. September 2016. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036835/
5.Coviello, A. D., Kaplan, B., Lakshman, K. M., Chen, T., Singh, A. B., Bhasin, S., “Effects of graded doses of testosterone on erythropoiesis in healthy young and older men”, The Journal of clinical endocrinology and metabolism, vol.93 issue 3, pp. 914–919. March 2008. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266950/
6.Resnick, S.M., Matsumoto, A.M., Stephens-Shields, A.J., Ellenberg, S.S., Gill, T.M., Shumaker, S.A., Pleasants, D.D., Barrett-Connor, E., Bhasin, S., Cauley, J.A., Cella, D., Crandall, J.P., Cunningham, G.R., Ensrud, K.E., Farrar, J.T., Lewis, C.E., Molitch, M.E., Pahor, M., Swerdloff, R.S., Cifelli, D., Anton, S., Basaria, S., Diem, S.J., Wang, C., Hou, X., Snyder, P.J., “Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment”, Journal of the American Medical Association. Vol.317 issue 7, pp.717–727. 2017. Available: https://jamanetwork.com/journals/jama/fullarticle/2603930
7.Spitzer, M., Basaria, S., Travison, T. G., Davda, M. N., DeRogatis, L., Bhasin, S., “The effect of testosterone on mood and well-being in men with erectile dysfunction in a randomized, placebo-controlled trial”. Andrology, vol.1 issue 3, pp.475–482. March 2013. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630276/
8.Wein, H., “Understanding How Testosterone Affects Men”, NIH Research Matters. September 2013. Available: https://www.nih.gov/news-events/nih-research-matters/understanding-how-testosterone-affects-men
9.Funder, J.W., “The multiple actions of testosterone in men: nature knows best”, Asian Journal of Andrology, vol.16 issue 2, pp. 266-267. March – April 2014. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955337/
10.Handelsman, D.J., “Androgen Physiology, Pharmacology, Use, and Misuse”, Endotext. October 2020. Available: https://www.ncbi.nlm.nih.gov/books/NBK279000
11.”Testosterone enanthate,” DrugBank. Available: https://go.drugbank.com/drugs/DB13944
14.”Testosterone Pregnancy and Breastfeeding Warnings”, Drugs.com. Available: https://www.drugs.com/pregnancy/testosterone.html

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