Tretinoin TAN Cream

Overview of Tretinoin TAN Cream

Dosage Strength

  • Tretinoin TAN Sensitive Cream (Tretinoin / Azelaic Acid / Niacinamide) 0.015/4/4% 30 mL Pump
  • Tretinoin TAN Mild Cream (Tretinoin / Azelaic Acid / Niacinamide) 0.03/4/4% 30 mL Pump
  • Tretinoin TAN Strong Cream (Tretinoin / Azelaic Acid / Niacinamide) 0.045/4/4% 30 mL Pump

General Information

Tretinoin
Tretinoin is one of the most bioactive forms of retinoids, which are vitamin A derivatives and are often referred to as all-trans retinoic acid (ATRA). Tretinoin, which was first examined more than 30 years ago, is frequently used topically to treat acne vulgaris and as a palliative for photoaging symptoms such face wrinkles, roughened skin, and liver spots. 1 It can be used alone or in conjunction with other drugs to treat skin conditions and has comedolytic and anti-inflammatory effects.

Oral Tretinoin has also been proven to be helpful in the treatment of certain tumors, including refractory acute promyelocytic leukemia (APL), which is identified by the chromosomal translocation t(15, 17), and in patients who are unable to take chemotherapy that uses anthracyclines. 1

Azelaic Acid
Azelaic acid is a naturally occurring substance that is used topically to treat rosacea, acne vulgaris, and other inflammatory skin disorders. Malassezia furfur, commonly known as Pityrosporum Ovale, a type of fungus that naturally grows on human skin, can likewise create this straight-chain dicarboxylic acid. Although the exact mechanism is unclear, azelaic acid is thought to have its effects by preventing cellular production in both aerobic and anaerobic bacteria. Although its mechanism of action is unclear, azelaic acid is generally well tolerated and has few adverse effects; nonetheless, some persons have reported mild to moderate itching and xerosis symptoms after applying the substance topically. 23

Niacinamide
Niacinamide, sometimes called nicotinamide, is a water-soluble B-complex vitamin derivative. Niacinamide adenine dinucleotide (NAD) and niacinamide adenine dinucleotide phosphate are precursors of this cofactor (NADP). Key elements of numerous important metabolic pathways in the human body include NAD and NADP. Foods including meats, liver, yeast, dairy products, legumes, beans, nuts, seeds, green leafy vegetables, fortified bread, cereals, coffee, and tea are among the sources of this nutrient. Niacin deficiency causes pellagra, a disorder characterized by dementia, rashes, and diarrhea.

Dermatologists utilize topical niacinamide clinically to treat a range of skin problems. Niacinamide is used to treat skin conditions such bullous pemphigoid, IgA bullous dermatosis, acne vulgaris, and some types of pruritus because of its capacity to suppress procytokine inflammatory pathways. Studies have showed a decrease in face spots and skin erythema when niacinamide is applied topically along with kinetin. It also has a synergistic effect when used with other topical anti-aging drugs. 45

References

1.Yoham AL, Casadesus D, “Tretinoin”. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557478/
2.”Azelaic acid”, Drug Bank.[Online]. Available: https://go.drugbank.com/drugs/DB00548
3.J. E. Frampton, A. J. Wagstaff, “Azelaic Acid 15% gel in the treatment of papulopustular rosacea”, The American Journal of Clinical Dermatology, vol.5, issue 1, pp. 57 – 64, 2004.
4.PC Chiu, CC Chan , HM Lin, HC Chiu, “The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial”, Journal of Cosmetic Dermatology vol.6, issue 4, pp. 243 -249, December 2007. Available: https://pubmed.ncbi.nlm.nih.gov/18047609/
5.E. Forbat, F. Al-Niaimi, FR. Ali, “Use of nicotinamide in dermatology”, Clinical and Experimental Dermatology vol.42, issue 2, pp. 137 – 144, March 2017. Available: https://pubmed.ncbi.nlm.nih.gov/28052374/
6.N. Schmidt, G.H. Eugene, “Tretinoin: A Review of Its Anti-inflammatory Properties in the Treatment of Acne.” The Journal of clinical and aesthetic dermatology vol. 4, issue 11, pp. 22 – 29, 2011. Available: https://www.ncbi.nlm.nih.gov/books/NBK557478/
7.M. Zasada, E. Budzisz, “Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments.” Advances in Dermatology and Allergology vol 36 issue 4, pp. 392–397. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791161/
8.”Tretinoin”, Drug Bank. [Online]. Available: https://go.drugbank.com/drugs/DB00755
9.A. Zalewska, “Azelaic acid hyperpigmented lesions treatment”, Case Reports and Clinical Practice Review vol.3 issue 3 pp. 204 -207.
10.D.L. Bissett, K. Miyamoto, P. Sun, J. Li, C.A. Berge, “Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin1”. International Journal of Cosmetic Science vol 26, pp. 231 – 238
11.J.E. Thatcher, “The role of CYP26 enzymes in retinoic acid clearance”. Expert Opinion Drug Metabolism Toxicology vol.5 issue 8, pp. 875 – 886. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730205/
12.”Niacin”, Drug Bank. [Online]. Available: https://go.drugbank.com/drugs/DB00627
14.”Azelaic acid – Drug Summary”, Prescribers’ Digital Reference. Available: https://www.pdr.net/drug-summary/Azelex-azelaic-acid-1111#:~:text=An%20occlusive%20dressing%20should%20not,physician%20if%20ocular%20irritation%20persists.

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