Tri-Amino Injection

Overview of Tri-Amino Injection

Dosage Strength

L-Arginine HCl / L-Citruline / L-Ornithine 100/100/100 mg/mL 30 mL Vial

General Information

L-Arginine, L-Citrulline, and L-Ornithine are the three conditional, non-essential amino acids that make up tri-amino injection. These three amino acids can be crucial for:

  • Cardiovascular health
  • Vasodilation (blood flow)
  • Erectile function
  • General health and longevity

Three groups of amino acids are distinguished: essential, optional, and conditional.1

Essential Amino Acids: Since the body is unable to create them on its own, essential amino acids must be obtained from food sources.

Adults only need to obtain eight of the twenty essential amino acids—valine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, and tryptophan—from dietary sources. Histidine, the ninth amino acid, is solely necessary for babies. Because amino acids cannot be stored by the body, a consistent daily intake of these vital protein building blocks is required. 1

The terms “non-essential” and “conditional amino acids” are misleading because certain amino acids do serve vital functions. They are not regarded necessary for health because the body can produce them, not because they are not. 2

Eight of these eleven non-essential amino acids are referred to be conditional amino acids because they may not be produced in sufficient quantities by the body in times of stress or illness. 2

Arginine, ornithine, glutamine, tyrosine, cysteine, glycine, proline, and serine are some of the conditional amino acids.

Although the body can use amino acids to make energy, building proteins is their main purpose. Some amino acids may also serve purposes other than protein synthesis, such as those involved in the production of hormones or neurotransmitters. 3

The twenty amino acids the body needs to function each have a distinct molecular structure. A protein is made up of fifty to two thousand different amino acids, which are connected to one another in a specific order based on precise (genetic) instructions.

References

1.Peter J. Reeds. Dispensable and Indispensable Amino Acids for Humans. J Nutr. 2000 Jul;130(7):1835S-40S.
2.Yarandi, Shadi S. et al. “Amino Acid Composition in Parenteral Nutrition: What Is the Evidence?” Current opinion in clinical nutrition and metabolic care 14.1 (2011): 75–82. PMC. Web. 29 Sept. 2017.
3.Wu G. Amino acids: metabolism, functions, and nutrition. Amino Acids. 2009 May;37(1):1-17. doi: 10.1007/s00726-009-0269-0. Epub 2009 Mar 20.
4.Critical Care201519:204.https://doi.org/10.1186/s13054-015-0881-1. Piton and Capellier; licensee BioMed Central. 2015. Published: 1 May 2015.
5.Elam RP, Hardin DH, Sutton RA, Hagen L. Effects of arginine and ornithine on strength, lean body mass and urinary hydroxyproline in adult males. J Sports Med Phys Fitness. 1989 Mar;29(1):52-6.
6.Cynober, L. “Can Arginine and Ornithine Support Gut Functions?” Gut 35.1 Suppl (1994): S42–S45. Print.
7.M.W.Radomski, R.M.J.Palmer, S.Moncada. Characterization of the L-arginine: nitric oxide pathway in human platelets. Br.J.Pharmacol.(1990),101,325-328.
8.Cardiology Research and Practice.Volume 2012 (2012), Article ID 656247, 7 pages. http://dx.doi.org/10.1155/2012/656247
9.Effects of arginine and ornithine on strength, lean body mass and urinary hydroxyproline in adult males. (PMID:2770269)
10.Misaizu, Akane et al. “The Combined Effect of Caffeine and Ornithine on the Mood of Healthy Office Workers.” Preventive Nutrition and Food Science 19.4 (2014): 367–372. PMC. Web. 29 Sept. 2017.
11.Luiking, Yvette C., Mariëlle P.K.J. Engelen, and Nicolaas E.P. Deutz. “REGULATION OF NITRIC OXIDE PRODUCTION IN HEALTH AND DISEASE.” Current opinion in clinical nutrition and metabolic care 13.1 (2010): 97–104. PMC. Web. 29 Sept. 2017.
12.Baumgardt, Shelley L. et al. “Chronic Co-Administration of Sepiapterin and L-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice.” Circulation. Heart failure 9.1 (2016): e002424. PMC. Web. 29 Sept. 2017.
13.Oral L-Citrulline Supplementation Improves Erection Hardness in Men With Mild Erectile Dysfunction. Cormio, Luigi et al. Urology , Volume 77 , Issue 1 , 119 – 122
14.Yi, Jing et al. “L-Arginine and Alzheimer’s Disease.” International Journal of Clinical and Experimental Pathology 2.3 (2009): 211–238. Print.
15.Jahangir, Eiman et al. “The Effect of L-Arginine and Creatine on Vascular Function and Homocysteine Metabolism.” Vascular medicine (London, England) 14.3 (2009): 239–248. PMC. Web. 29 Sept. 2017.
16.Scibona M, Meschini P, Capparelli S, Pecori C, Rossi P, Menchini Fabris GF. L-arginine and male infertility. Minerva Urol Nefrol. 1994 Dec;46(4):251-3.
17.Sandrini G, Franchini S, Lanfranchi S, Granella F, Manzoni GC, Nappi G. Effectiveness of ibuprofen-arginine in the treatment of acute migraine attacks. Int J Clin Pharmacol Res. 1998;18(3):145-50.
18.Yu Cao, Yonghui Feng, Yanjun Zhang, Xiaotong Zhu and Feng Jin. L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo. BMC Cancer201616:343
19.Gullett, Norleena P. et al. “Nutritional Interventions for Cancer-Induced Cachexia.” Current problems in cancer 35.2 (2011): 58–90. PMC. Web. 29 Sept. 2017.
20.Bower RH1, Cerra FB, Bershadsky B, Licari JJ, Hoyt DB, Jensen GL, Van Buren CT, Rothkopf MM, Daly JM, Adelsberg BR. Early enteral administration of a formula (Impact) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: results of a multicenter, prospective, randomized, clinical trial. Crit Care Med. 1995 Mar;23(3):436-49.
21.Höche F, Klapperstück T, Wohlrab J. Effects of L-Ornithine on metabolic processes of the urea cycle in human keratinocytes. Skin Pharmacol Physiol. 2004 Nov-Dec;17(6):283-8.
22.National Center for Biotechnology Information. PubChem Compound Database; CID=6262, https://pubchem.ncbi.nlm.nih.gov/compound/6262 (accessed Sept. 29, 2017).
23.http://www.mayoclinic.org/drugs-supplements/arginine/interactions/hrb-20058733
24.http://www.mayoclinic.org/drugs-supplements/arginine/interactions/hrb-20058733

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