Wart Remove 5-FU Ointment

Overview of Wart Remove 5-FU Ointment

Dosage Strength

Fluorouracil / Salicylic Acid 2.5/17% 5 mL Pump

General Information

A fluorinated pyrimidine called fluorouracil (5-FU) functions as an antimetabolite antineoplastic agent. It varies from uracil, a naturally occurring substance, by having a fluoride added at position 5. For many solid tumors, including breast, colorectal, gastrointestinal, and head and neck malignancies, fluorouracil is a part of chemotherapy regimens. The pharmacokinetics of 5-FU are compounded by intra- and inter-patient variability, nonlinear elimination, and inconsistent bioavailability, which add to the drug’s complex clinical pharmacology. The drug’s delivery route affects the drug’s toxicities and effectiveness. In a meta-analysis of 5-FU studies for the treatment of colorectal cancer, it was discovered that continuous infusion was superior to bolus injection in terms of response and overall survival rate, with a lower incidence of severe hematologic toxicity. However, compared to the bolus injection, the continuous infusion had a higher prevalence of hand-foot syndrome. 1 Although it is frequently administered intravenously, fluorouracil can also be applied topically to treat malignant skin keratoses. The FDA granted fluorouracil approval in 1962. The FDA authorized CaracTM, a novel fluorouracil cream formulation that uses a microsponge delivery mechanism. The novel delivery mechanism enables a prolonged release of fluorouracil and a single daily dose.

Salicylic Acid
A topical keratolytic agent is salicylic acid. In hyperkeratotic skin conditions such plantar and common warts, psoriasis, seborrheic dermatitis, calluses, and corns, it is used to eliminate extra keratin. Acne can also be treated with salicylic acid. Salicylic acid functions by inducing the horny layer of skin to desquamate. Salicylism may be caused by prolonged or daily application across broad areas of skin, especially in youngsters and people with renal or hepatic impairment. The FDA authorized this medication in 1939. 23456789


1.No authors listed. Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. Meta-analysis Group In Cancer. J Clin Oncol 1998;16:301-308.
2.Compound W (salicylic acid 17%) package insert. Tarrytown, NY: Prestige Brands; 2013 Mar.
3.Compound W gel (salicylic acid 17% gel) package insert. Tarrytown, NY: Prestige Brands; 2013 April.
4.Hydrisalic gel (salicylic acid 17%) package insert. Farmingdale, NY: Pedinol Pharmacal Inc.; 2011 Nov.
5.Virasal (salicylic acid 27.5%) package insert. Vernon Hills, IL: Elorac, Inc.; 2011 Jan.
6.Salex 6% (salicylic acid) cream and lotion package insert. Bridgewater, NJ: Valeant Pharmaceuticals North America LLC; 2019 Jan.
7.Salacyn 6% (salicylic acid 6%) cream or lotion package insert. Miami, Fl: Stratus Pharmaceuticals Inc.; 2010 Nov..
8.Salitech (salicylic acid 5% lotion) package insert. Peoria, AZ: Solutech Pharmaceuticals; 2016 Dec.
9.Salisol (salicylic acid 23% topical solution) package insert. Peoria, AZ: Solutech Pharmaceuticals; 2016 Dec.
10.Salvax 6% foam (salicylic acid) package insert. Newtown, PA: Quinnova Pharmaceuticals, Inc.; 2009 Apr.
11.Diasio RB. Oral administration of fluorouracil: A new approach utilizing modulators of dihydropyrimidine dehydrogenase activity. Cancer Therapeutics 1999;2:97-106.
12.Adrucil (fluorouracil injection) package insert. Irvine, CA: Teva Parenteral Medicines, Inc.; 2007 July.
13.Efudex (fluorouracil) solution and cream package insert. Bridgewater, NJ: Valeant Pharmaceuticals North America LLC, 2016 Feb.
14.Carac (fluorouracil) cream package insert. Bridgewater, NJ: Dermik Laboratories; 2009 Aug.
15.Tolak (fluorouracil) 4% topical cream package insert. Sanford, FL: Hill Dermaceuticals, Inc.; 2015 Sep.
16.Cosmetic Ingredient Review Expert Panel. Safety assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl Salicylate, Isocetyl Salicylate, Isodecyl Salicylate, Magnesium Salicylate, MEA-Salicylate, Ethylhexyl Salicylate, Potassium Salicylate, Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate, and Tridecyl Salicylate. Int J Toxicol 2003;22 (Suppl 3):1-108. Review.
17.Fluorouracil injection package insert. New York, NY: Pfizer Labs; 2012 Aug.
18.Topical fluorouracil 5% cream package insert. Hawthorne, NY: Taro Pharmaceuticals U.S.A. Inc.; 2010 Feb.
19.Topical fluorouracil 2% or 5% solution package insert. Hawthorne, NY: Taro Pharmaceuticals U.S.A. Inc.; 2010 Feb.
20.Floyd J, Mirza I, Sachs B, et al. Hepatotoxicity of chemotherapy. Semin Oncol 2006;33(1):50-67.
21.National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC). General recommendations on immunization: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2011;60(2):1-64.
22.Curad mediplast (salicylic acid 40%) package insert. Mundelein, IL: Medline Industries, Inc.; 2013 Feb.
23.Sargent DJ, Niedzwiecki D, O’Connell MJ, et al. Recommendation for caution with irinotecan, fluorouracil, and leucovorin for colorectal cancer. N Engl J Med 2001;345:144-145.
24.Pujol RM, Rocamora V, Lopez-Poussa A, et al. Persistent supravenous erythematous eruption: a rare local complication of intravenous 5-fluorouracil therapy. J Am Acad Dermatol 1998;39:839-42.
25.Fluoroplex (fluorouracil) cream package insert. West Chester, PA: Aqua Pharmaceuticals; 2012 Mar.
26.Food and Drug Administration MedWatch. Over-The-Counter Topical Acne Products: Drug Safety Communication – Rare But Serious Hypersensitivity Reactions. Retrieved June 25, 2014. Available on the World Wide Web http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm402722.htm?source=govdelivery&utm_medium=email&utm_source=govdelivery

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