Zomacton Injection
Overview of Zomacton Injection
Dosage Strength
5 mg Lyophilized VialGeneral Information
A purified form of recombinant growth hormone known as somatropin, rh-GH, is produced by either Escherichia coli or mammalian cells. The pituitary gland is where endogenous human growth hormone (hGH) is created. The structure of growth hormone was discovered in 1972 after it was originally isolated in 1956. Growth hormone (GH) was previously generated from human cadavers prior to 1985, but its usage was discontinued as a result of Creutzfeldt-Jakob virus infection. Somatropin has been given the go-ahead to treat adults with short bowel syndrome as well as growth hormone deficit (GHD), growth failure, or short stature, cachexia, and AIDS wasting. Limited short-term results suggest that somatropin use may reduce visceral adipose tissue; the drug has been explored for the treatment of HIV-associated adipose redistribution syndrome (HARS). There are numerous somatropin medications available, each with unique indications and dose guidelines. It is important to choose products carefully because they could not be interchangeable. The FDA initially authorized somatropin in 1987.
References
1.Omnitrope (somatropin) package insert. Princeton, NJ: Sandoz, Inc.; 2016 Dec.
2.Genotropin (somatropin) package insert. New York, NY: Pharmacia & Upjohn Company; 2016 Dec.
3.Food and Drug Administration (US FDA) Drug Safety Communication. Safety review update of Recombinant Human Growth Hormone (somatropin) and possible increased risk of death. Retrieved August 4, 2011. Available on the WorldWide Web at: http://www.f
4.Albertsson-Wikland K, Martensson A, Savendalh L, et al. Mortality is not increased in recombinant human growth hormone-treated patients when adjusting for birth characteristics. J Clin Endocrinol Metab. 2016; 101: 2149-2159.
5.Humatrope (somatropin) package insert. Indianapolis, IN: Eli Lilly and Company; 2016 Dec.
6.Serostim (somatropin) package insert. Rockland, MA: EMD Serono, Inc.; 2017 May.
7.Nutropin (somatropin) package insert. San Francisco, CA: Genentech; 2016 Dec.
8.Accretropin (somatropin) package insert. Winnipeg, Canada: Cangene Corporation; 2016 Dec.
9.Nutropin AQ (somatropin) package insert. San Francisco, CA: Genentech; 2016 Dec.
10.Saizen (somatropin) package insert. Rockland, MA: EMD Serono Inc; 2017 May.
11.Norditropin (somatropin) package insert. Plainsboro, NJ: Novo Nordisk; 2016 Dec.
12.Zomacton (somatropin) package insert. Parsippany, NJ: Ferring Pharmaceuticals, Inc; 2016 Dec.
13.Zorbtive (somatropin) injection package insert. Rockland, MA: EMD Serono, Inc.; 2017 May.
14.Cook DM, Yuen KC, Biller BM, et al; American Association of Clinical Endocrinologists (AACE). American Association of Clinical Endocrinologists medical guidelines for clinical practice for growth hormone use in growth hormone-deficient adults and
15.The American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2015;63:2227-46.
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